Target achieved: smooth and young skin for longer
An alternative mechanism against expression wrinkles. Leuphaysl inhibits muscular contraction through Ca2+

Luphasyl is a Pentapeptide tha mimics the natural path of enkephalins, acting on expression wrinkles formation in a new way. This alternative mechanism offers compatibility with other anti-wrinkle peptides, providing and additive and synergistic effect.


Leuphacyl reduces the depth of wrinkles caused by the contraction of muscles of facial expression, decreasing neuron excitability and modulating acetylcholine secretion. The diminution of wrinkles increases with argireline, due to this additive effects.


Leuphasyl can be incorporated in cosmetic formulations where removal of wrinkles, especially in the forehead and around the eyes is desired.

Expression wrinkles are a particular type linked to repeated muscular contraction and they usually appear as soon as the age of 30. Musclesare contracted when they receive acetylcholine released from a vesicule in the neuronal exocytosis. In order to fuse a vesicle with the cellular membrane, two events are required: the SNARE complex formation and the entry of calcium ions into the neurons.

Leuphaysl is a modified enkephalin that couples to the enkephalin receptor, outside of nerve cells. This association releases G protein subunits (α, β, Y), which close calcium channels avoiding vesicle fusion and consequently inhibiting acetylcholine release across the synapse. This process maintains the neuron in its resting state, attenuating muscle contraction and preventing the formation of lines and wrinkles.
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